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Colchicine is neither analgesic nor anti-inflammatory.

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6 mg was administered with clarithromycin 250 mg bid for 7 days, the colchicine cmax increased 197 and the auc0- increased 239 compared to administration of colchicine alone.

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since colchicine is an established mutagen, its ability to act as a carcinogen must be suspected and administration of probenecid and colchicine should involve a weighing of the benefit-vs-risk when long-term administration is contemplated.


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